Pediatric patients with sickle cell disease present unique challenges in the prehospital setting, particularly when infection, neurologic changes, and stroke risk intersect. Early recognition and timely decision-making by prehospital providers can significantly influence patient outcomes, yet these presentations may be subtle and easily overlooked in the field. This case study examines a pediatric patient with sickle cell disease who presented to prehospital providers with evolving neurologic symptoms. Through a structured review of dispatch information, on-scene assessment, clinical decision points, and transport considerations, participants will explore the complexities of identifying stroke risk in this high-risk population. Emphasis is placed on recognizing red flags, understanding the role of infection and systemic illness, and communicating critical findings to receiving facilities. This session aims to increase confidence in prehospital stroke recognition for pediatric sickle cell patients and reinforce the importance of early activation and interdisciplinary coordination.

NYS CME: All Levels - Core - Neurology