Cannabis, ketamine, and psychedelics all have purported benefits in a variety of clinical situations, but how do they work and how can they be used to treat pain, depression, and PTSD among other conditions. What are the dangers of these substances? In this rapid-fire overview of this contemporary topic we will answer these questions. We will also discuss the current literature and future research directions. Finally, we’ll cover challenges that shape the therapeutic use of these substances. Core: Toxicology