This session will feature an exciting cage match-style debate discussing cutting-edge evidence on the pharmacologic interventions used in pre-hospital cardiac arrest care. The discussion will address the hotly debated question: "Naloxone for everyone?"—exploring the latest data on its effectiveness in patients experiencing cardiac arrest from opioid overdose and its broader application. The session will also critically examine the role of epinephrine in resuscitation, reviewing recent studies that either support or question its benefits in improving survival and neurological outcomes. We will break down which medications actually work, examining the evidence behind epinephrine, amiodarone, and lidocaine in the management of ventricular arrhythmias, and norepinephrine vs. epinephrine in post-ROSC care. By presenting groundbreaking research and real-world case studies, this presentation will provide EMS providers with the insights needed to make informed decisions on medication use during critical care situations, ensuring they are utilizing the most effective treatments available. Core: Pharmacology